My Life Simulator

My Life Simulator Chapter 357

2021-10-14

Chapter 356 We are witnessing history

"Go, let's go to the Cancer Institute!"

After reading Lu For Li's paper, Professor He hurriedly got up, "Let's go to the laboratory to verify it."

If it is an irrigation paper, naturally there is no need for verification. Lu Li's research value is extremely high, and it can even be said that it is a pioneering achievement of the Great Accomplishment. Naturally, it must undergo comprehensive and meticulous verification.

So, Professor He and Lu Li hurried out of the office and headed to Fudan Cancer Institute.

"Lao Guo, Lao Guo, come on!"

Walking into the Cancer Institute, Professor He held up the papers in his hands and shouted all the way.

"I'm here! I'm here!"

Professor Guo's head popped out of the office door.

Seeing Professor He running over excitedly, with Lu Li behind him, Professor Guo hurriedly asked, "Old He, why are you yelling so much?"

p>

"Lu Li has published research results, quickly organize the staff to verify it."

Professor He is walking fast, shouting as he walks.

Research results?

Hearing Professor He's words, Professor Guo was stunned for a moment, his eyes looking towards Lu Li were a little horrified.

This is the result?

It has only been more than two months since the last release of the improvement plan for CAR-T technology? Results again?

The busy graduate students and Academician students next to them also stopped one by one and looked towards Lu Li one after another, thinking to themselves: Why are you getting results again?

"Old Guo, come and have a look!"

Professor He walked into Professor Guo's office in a few steps with a red light on his face and walked into Professor Guo's hand. With a stoppage, "Quick, organize verification."

"What are you panicking about? I'll take a look first!"

Professor Guo was still calm and ignored Professor He's shouting. Xiao Ye, took over the thesis materials and looked at it.

"The application of gene editing technology for T cells and B cells in CAR-T technology."

Application?

Seeing this keyword, Professor Guo's eyes twitched a few times. Dare to write the application on the title, is it... Lu Li is sure that this technology has matured?

CAR-T technology is mature, what is the concept?

As the research leader of the Cancer Research Center, how could Professor Guo not know about CAR-T technology?

This new technology is still in the exploratory stage. Once it matures, it means that it has found a special drug for cancer treatment, and found the most reliable technology for cancer treatment.

From a clinical point of view, this has already been considered to conquer cancer!

If this technology is true, if it is really feasible and reliable after verification, then... Lu Li's scientific research results will be a great historical breakthrough!

We are witnessing history!

Professor Guo set off a heaven overflowing giant wave in his heart, and the hand holding the document was shaking slightly.

took a deep breath, Professor Guo raised his glasses and looked towards this paper seriously.

Study carefully and carefully, word by word.

Modifies T cells, putting cancer cells on the "hostile list" and weakening the ability of T cells to "summon friend". This is the result of previous research by Lu Li.

Now, in this paper, Lu Li has given a new idea. On the basis of modifying the genes of T cells, Lu Li further modified the genes of B cells, so that B cells are shielded from "logistics and command ability".

In theory, Lu Li's idea is correct and feasible.

It's just...to achieve this goal, it involves very specific gene editing modification technology.

To accurately modify a certain function of B cells, a very specific and very precise gene editing operation is also required, and it is very likely that the genetic operation to modify a certain function of B cells will not be possible for a long time. .

"The idea is right."

After reading the paper, Professor Guo nodded, and glanced at Professor He and Lu Li, "However, it is too much to talk about application. Is it early? This is just a directional theoretical research paper, and it cannot enter the practical application link."

Putting down the paper in his hand, Professor Guo glanced at Lu Li and the two and said: " To accurately edit the genes of B cells, it will take a long time to study the gene target and select the gene segment we want to edit. Let's do this research first."

"No need!"

Professor He laughed and took out another document, "The experiment has been done. This is the experimental report."

"Huh?"

p>

Professor Guo stared wide-eyed, "Has it been made?"

He hurriedly grabbed the experimental report from Professor He, and Professor Guo looked at it seriously again.

In this experimental report, Lu Li wrote out each step of the experiment in detail, and wrote out various detailed data such as reaction time, ambient temperature, humidity, and equipment meter readings.

This...is it really successful?

Lu Li has completed all the experimental steps, only one result is needed for verification.

Professor Guo lifts the head to look towards Lu Li, the corners of his mouth are trembling, "You...have completed all the techniques for genetic modification of B cells?"

"Yes! "

Lu Li nods, "We are here this time, and B is here to verify the results." The technology has come out. How did you pinpoint the gene segment? How did you locate it?”

Professor Guo was still a little unbelievable.

I did my first experiment in the virtual lab!

In the past two months in reality, I didn't know how many more experiments I had in the virtual laboratory, and I don't know how much time it took to find the exact gene segment.

Of course, Lu Li can't say that. He can only say: "Maybe it's good luck, right? It happened to let me find the gene segment needed for B cell gene editing."

Luck ...

This reason is so powerful that Professor Guo is speechless.

Research is a process of trial and error. In this infinite trial and error link, luck is first.

Unfortunately, maybe you can't find the desired gene segment from the three billion base pairs in a year or two, or even a dozen years.

With good luck... Maybe just like Lu Li, he found his goal in just over two months.

So, even scientists have to talk about luck.

"Go! Let's verify it right away!"

Professor Guo didn't struggle with luck, got up quickly, walked out of the office, and shouted at the busy graduate student Academician outside: "Stop what you're doing, go to the genetic laboratory immediately, and verify the scientific research results, hurry up!"

Another scientific research results verification?

It is the verification of Lu Li's scientific research results again?

They are all hard-working scientific research dogs. We can only follow the mentors to mix experience, but you continue to produce scientific research results.

It's so... so self-respecting!

The scientific research dogs driven by Professor Guo ran up and down one by one, but bowed their heads slightly when they passed by Lu Li.

Everyone came to the genetic laboratory. Professor Guo asked Lu Li to lead the experiment and instructed many scientific dogs to do the experiment.

A group of graduate students and Academician students gave Lu Li a hand to continuously extract B cell samples, prepare transcriptases, and prepare spliced proteins.

Lu Li was sitting in front of the test bench, and all kinds of experimental materials were continuously collected into Lu Li's hands.

Turning on the electronic Microscope and turning on the gene gun, Lu Li kept editing the B cells, making samples one by one, more than a hundred times in a row.

"The test passed! The genetic modification specimens have been obtained."

After Lu Li completed more than 100 genetic modifications, Professor Guo, who carried out the test later, has found that the genetic modification has been accurately completed. Genetically modified B cell specimens.

"Success! The B cell gene editing technology has been verified successfully!"

Next to him, Professor He couldn't help cheering.

"Congratulations!"

"Lu Li, congratulations!"

There was a round of applause in the laboratory, and everyone was impressed by Lu Li's technology Congratulations on successful verification.

This verification has proved that Lu Li's B cell gene editing technology is successful.

It is quite normal that it takes more than 100 times to accurately prepare the required genetically modified specimens.

The current gene editing technology, even if the gene segment to be edited is identified, the splicing protein and transcriptase are impossible to cut exactly the desired position at one time, and often cut the wrong place.

It took one hundred experiments to get a sample with the correct gene editing. This is why Lu Li confirmed the experimental data. This result is already very good.

If you don't have this experimental data, you don't know how many years of experiments you have to do before you happen to hit the right spot!

"The B cell gene editing technology has been verified!"

Professor Guo also announced the results with excitement, and then said: "The next thing to do is to The verification of CAR-T anti-cancer technology has been completed."

"This verification will take some time."

Professor He took the conversation and turned to Lu Li and said with a smile: "However, your theoretical research paper can be published. The experimental data must be kept secret!"

"Understood!"

Lu Li nods, "The results of anti-cancer technology are verified. I still need to ask Professor Guo to arrange it."

"No problem."

Professor Guo agreed without the slightest hesitation.

……

In the afternoon, China Medical Journal received another paper from Fudan University.

"The application of gene editing technology of T cells and B cells in CAR-T technology."

Seeing this title, the editor of "Chinese Medicine" was very nervous, application? Is CAR-T technology mature?

See the author of the paper again...Lu Li!

It's Lu Li again!

It's only been a few months? Has Lu Li researched CAR-T technology to the extent that it can be applied?

Editors are also half insiders, and naturally know the significance of the maturity of CAR-T technology, which is equivalent to declaring to the world that cancer is no longer a terminal illness, and cancer can already be treated!

This Lu Li... is really amazing!

With a deep admiration in my heart, the editor of the magazine, without the slightest hesitation, quickly forwarded the paper by Lu Li to the reviewer.

......

"Currently, CAR-T technology is not yet mature."

In a large auditorium of Yanjing University, oncology experts, Professor Wang Zhijian from Xiehe Medical College is giving an open class.

"Fudan's young student Lu Li has achieved a major breakthrough in this technology. However, the problem of immune factor storm has still not been solved."

"Science and Technology With each passing day, I believe that with the passage of time, maybe five years, maybe ten years, we will be able to overcome cancer, a chronic disease that exists along with human genes."

"Of course, this requires the students present here. Everyone, study hard and study hard!"

As he was talking, Professor Wang Zhijian suddenly saw his assistant holding up his mobile phone and waving at him, looking a little excited and a little anxious.

Huh? what happened?

Professor Wang Zhijian frowned. This assistant is his student. It stands to reason that the assistant is impossible to disturb him during class.

Since the assistant does this, there must be something very important.

"What's the matter?"

Professor Wang Zhijian stopped, turned his head and looked towards the assistant, his face a little displeased.

"Professor, China Medical Journal, I have transferred a manuscript for your review."

The assistant raised the phone and answered quickly.

"Review? That's all?"

Professor Wang Zhijian's face was a little ugly, "Just this matter, you dare to interfere with my class?"

"Professor, this manuscript... is very important!"

The assistant said quickly: "This is Lu Li's paper. The latest paper on CAR-T technology."

Uh ?

Professor Wang Zhijian was shocked, Lu Li? CAR-T latest technology?

"Bring it here!"

It is absolutely important to send in the manuscript for viewing at the risk of interfering with the class. Professor Wang Zhijian hurriedly asked his assistant to bring the phone over.

Because the audio equipment was not turned off for this conversation, the students sitting in the auditorium also heard this conversation.

So...the classroom was suddenly discussed spiritedly.

“Lu Li? Is that the Lu Li from Fudan?”

“Lu Li has developed a new technology again?”

“Since you dare to disturb Wang A professor's class must be an important paper."

"Did Lu Li have another breakthrough in CAR-T technology? Did he mature this technology?"

"It should be impossible. Didn't you hear what Professor Wang said? It will take five years, or even ten years, to develop a mature CAR-T technology."

The students discussed spiritedly in the audience At the time, Professor Wang Zhijian was a little stunned.

"The application of gene editing technology for T cells and B cells in CAR-T technology."

This is a theoretical paper, which discusses the gene editing of T cells and B cells. Editing technology, made a directional statement.

This kind of theoretical research paper can only be used as a reference and does not have much practical application value.

However, the title of this paper dares to write the word "application", and at the back of the paper, there are repeated experimental conclusions of Fudan University.

This means...the technology has been proven. Lu Li's paper is absolutely correct, at least in terms of genetic modification techniques for B cells.

the younger generations will surpass us in time!

Professor Wang Zhijian suppressed the shock in his heart, put down his mobile phone, and walked to the podium again.

"Students, I just received a paper."

Professor Wang Zhijian said to the students in the audience: "This is a paper published by Lu Li of Fudan University, about CAR-T technology paper."

"In this paper, Lu Li proposed a new research direction and completed the preliminary verification."

Speaking of this, Professor Wang Zhijian paused for a while, and then said, "Just now, I said that CAR-T technology will take five years, or even ten years to mature, maybe... I was wrong!"

"Although Lu Li's research The new generation of CAR-T technology that comes out still needs clinical trials to prove its efficacy. However, in theory, maybe... he has conquered cancer! From now on, cancer is no longer a terminal disease!"

"Fuck!"

"My God!"

At this moment, there was an uproar in the audience.

(end of this chapter)