My Life Simulator

My Life Simulator Chapter 356

2021-10-14

Chapter 355 Have you conquered cancer?

After preparing this B cell, Lu Li immediately began human experiments.

This is another huge advantage of the virtual lab.

If it is a normal experimental procedure, experiments must be carried out on various small animals first, and after a long period of time, it is possible to carry out human experiments.

Even... a lot of scientific research projects simply don't have the chance to be approved for human experimentation.

Lu Li is different.

In the virtual lab, everything is virtual, and everything is fake. He can do human experiments at will, and he can do whatever he wants, without any restrictions at all.

The same goes for this time.

Lu Li directly injected the modified B cells into the experimental human body.

And then... nothing happened.

Huh? how come?

Lu Li was taken aback for a moment, then quickly picked up the testing equipment and carefully inspected the experimental human body.

Then, Lu Li found the reason!

B cells that block the ability to receive information are also a "quiet handsome man"!

Without receiving any information, it returns to the lymph nodes with the lymph fluid, staying motionless and leisurely inside.

On the contrary, other B cells that exist in the human body, after receiving the information, reproduce wildly, release immune factors frantically, and cause the immune system to go crazy.

So...B-cell "shutdown" doesn't work either!

What's going on here?

Lu Li's head hurts!

Forget it, take a break. For more than a month, I have stayed at home every day to do research, and everyone has rusted!

Closing the virtual lab, Lu Li got up and went out, circled the artificial lake in Riverside Garden, and started running!

As he was running, Lu Li suddenly saw a girl in front of her doing morning exercises.

This girl is wearing a white tight-fitting sportswear.

Fortunately, Lu Li's will is as strong as steel, and even when he sees this sultry scene, his heart does not fluctuate.

I'm even thinking...the weight of the chest and buttocks is too large, which affects the coordination of human movement. This kind of body structure does not conform to the laws of nature. In the cruel natural competition, it will definitely be eliminated by natural selection!

Next moment, Lu Li thought again... Humans no longer need to suffer cruel natural selection! This body structure is more suitable for gene transmission.

So, what is going on in the research dog's mind?

While Lu Li was thinking about serious scientific issues, the sultry girl heard the footsteps behind her and turned her head to look over.

Seeing Lu Li's handsome face, slender and straight body, and strong muscles, this girl's eyes flashed a ray of light, and a smile appeared on her face.

"Hi!"

The girl waved to Lu Li and said hello.

Uh...because of my handsome appearance and my strong body, I am very suitable as a combination of genetic transmission, so under the control of genetic instinct, she took the initiative to greet me.

Sure enough, humans are just tools dominated by genes!

Love is only the instinct of gene transmission, family love is only the instinct to protect the continuation of genes, and human beings are only tools dominated by genes.

As a series of scientific explanations popped up in his head, Lu Li smiled back to complied "Hi!"

Nothing else, mainly...too big!

It's still a genetic instinct!

"Do you live here too? Why haven't I seen you before?"

The girl slowed down and ran alongside Lu Li.

"I've lived here for more than a year."

Lu Li replied and asked, "Do you live here too? I haven't seen you before!"

"I just came a few days ago!"

The girl laughed, "I used to be in Beijing. My sister lives here. I'm here to see my sister!"

"Oh! Beijing is a good place!"

Lu Li nodded,"

I stayed in Beijing for a while. That was in the plot. In the plot of the best actor and the master of craftsmanship, Lu Li spent a long time in Beijing.

"Really?"

While running, the girl's pale face was sweating slightly, and she had the strange beauty of a jade plate rolling ball.

"My name is Wenwan, how about you?"

The girl introduced herself, then turned her head and asked Lu Li.

"My name is Lu Li."

"Lu Li?"

Before Lu Li finished speaking, the gentle girl burst out cry out in surprise , "You are the Lu Li who developed the new CAR-T technology? My God! didn't expect to meet you here, what a coincidence!"

"My popularity is not yet Is it that high?"

In today's society, people only pay attention to the lace news of celebrities, who cares about scientific research dogs?

"introduce myself. Wen Wan, a graduate student of basic medicine at Xiehe Medical College."

Wen Wan laughed at Lu Li, "Boss, don't you know how famous you are? Are you Our idol!"

"Oh! It's a peer!"

Lup Li nods! "No wonder you know me."

"Big Dude, add a WeChat!"

Wen Wan took out her mobile phone from her sports wrist bag and raised it towards Lu Li.

“WeChat?”

Lu Li step one stopped, and the dive light flashed in his mind.

Yes! WeChat!

My previous thinking was wrong!

Why shut down B cells? Why make B cells unable to receive information? I just need to make B cells unable to send "WeChat" and "Circle of Moments"!

B cells receive the information from dendritic cells, immediately activate the stress mechanism, and continue to divide and proliferate.

And then... after these genetic modifications, the B cells that "can't send WeChat" and "can't send friends circle" occupy the positions of other normal B cells in a large area, and then "dead meal", what's not Do!

In this way, the chance of immune factor outbreaks will be greatly reduced!

“Hahahaha!”

Lu Li laughed, turned around and ran away without a trace.

Behind her, the gentle girl has a dull face!

What do you mean? I asked you for a WeChat, is it so funny?

Also, what do you mean by running away like this?

Are all research dogs such straight men? You deserve it to die!

The gentle girl stomped her feet heavily, her face full of depression!

……

Lu Li suddenly became enlightened and found a breakthrough, where would he care about any girl?

Running home in a flash, Lu Li lay down on the sofa, eyes closed, and opened the virtual lab again, regardless of the sweat on his body.

"Virtual a human with advanced cancer!"

When he came to the virtual laboratory, Lu Li ordered it directly, put on a white coat in a hurry, and walked into the operating room .

After taking samples from the experimental human body and picking up several samples containing cancer cells, T cells and B cells, Lu Li hurriedly sat in front of the test bench and continued the experiment.

The CAR-T experiment was done first, and the required T cells were prepared. Lu Li took out the B cell samples and began to genetically modify the B cells.

In the right direction, the experiment went smoothly.

Lu Li modified the genes of B cells with splicing proteins, blocking the ability of B cells to transmit information to the outside world.

Then... Lu Li took the B cells and injected them into the experimental body. Then, using CAR-T technology, gene-edited T cells were also injected into it.

next moment...a miracle is born!

The "hostile sequence" of T cells discovered the cancer cells in the experimental human body, and immediately stimulated the immune mechanism, divided and proliferated frantically, and launched a violent attack on the cancer cells.

At this time, the T-cell army was dispatched, which made the "intelligence" dendritic cells aware of it, and quickly sent information to the B-cells, kept calling for reinforcements, and kept reporting the news of the "breakout of war".

Normal B cells are activated and immediately divide and proliferate. However... B cells whose genes have been modified by Lu Li are also proliferating violently.

In this way, many B cells of the "corpse meal" occupy the positions of logistics and command. Their inaction makes the immune mechanism work significantly slower.

The "immune factor storm" did not break out on a large scale, nor did it cause the immune system to go crazy.

Although the experimental body is still feverish and the immune response is still very strong, there is no phenomenon that the immune system attacks the vital organs indiscriminately, and does not lead to heart failure, lung failure, and other internal organ failures.

The experiment was successful!

Lu Li laughed heartily.

This kind of invigorating feeling of overcoming a scientific research problem and the sense of achievement of this kind of technological breakthrough made Lu Li very happy!

From a certain point of view, CAR-T technology already has clinical value!

It reduces the immune response, avoids the immune factor storm, and prevents the immune system from attacking the human body indiscriminately, but it can accurately kill cancer cells, which is the best way to treat cancer.

It's just...it's still not a complete cure.

Once T cells kill cancer cells in the body, they self-destruct and do not persist in the body for long.

And then...after a period of time, maybe three years, maybe five years, or ten years, the cancer cells will reappear.

A person who has had cancer has the genes of cancer cells imprinted in his DNA, and recurrence is inevitable!

Of course, after relapse, CAR-T technology can still be used for treatment!

However, this presents a new problem. Cancer cells are likely to have new mutations in the battle against T cells, and are likely to have the ability to resist T cell attacks.

Just like viruses constantly mutate, it is almost inevitable that cancer cells will evolve and mutate.

So... Although Lu Li came up with the best treatment for cancer, he still didn't conquer cancer fundamentally!

Lu Li is still not satisfied with his research results.

 …

After closing the virtual lab, Lu Li took a shower, changed his clothes, sat down at the computer desk again, and started writing his thesis.

“The application of gene editing technology of T cells and B cells in CAR-T technology.”

Lu Li put forward a new theory, in modifying the T cell "friend or foe recognition system" and On the basis of the ability to "call friendly forces", we further propose a plan to shield the command ability of B cells.

This is a mature technology that is ready for clinical application.

The paper is open to the world. In this paper, Lu Li only expresses theoretically, and does not express experimental data and specific operation methods.

Immature technology can be disclosed. Mature technology, it must be kept secret.

After writing this pure theoretical description paper, Lu Li wrote a detailed experimental report, which stated the experimental data and experimental steps.

This experimental report, Lu Li is going to hand over to Fudan Medical College. As for how to deal with this scientific research result, that is what the leaders consider!

After writing the thesis and the lab report, Lu Li took the test with a USB flash drive and rushed to Fudan Medical College.

"Little Lu, are you here?"

Seeing Lu Li's arrival, Professor He smiled and said hello, "Are you... submitting your graduation thesis?"

“en!”

Lu Li nods, “teacher, I wrote a paper, or a paper on CAR-T technology. Take a look.”

Having said that, Lu Li took out the USB flash drive and copied the papers and experimental reports into Professor He's computer.

"I have to take a good look at your graduation thesis!"

Professor He reached out and picked up the mouse, and clicked on Lu Li's thesis.

"The application of gene editing technology for T cells and B cells in CAR-T technology?"

Seeing this title, Professor He was shocked, turned his head, looked towards Lu Li, and continued to speak. Ask: "Application? You said application? Are you sure?"

The word application is not something you can write casually. Dare to say "application", it is a mature technology!

Is CAR-T technology mature enough to be applied?

Is Lu Li telling me that he has overcome cancer?

Professor He took a deep breath and felt that his heart was about to burst.

"I think this technology has matured. Please take a look first!"

Lu Li has already done human experiments. Real human experiments make no difference.

This technology has been proven!

"Okay! I'll take a look first!"

Professor He took a sip from the teacup, trying to suppress the shock and excitement in his heart, but...the hand holding the teacup They are shaking!

Concentrated, Professor He opened the thesis and read it carefully, word by word, from beginning to end.

After reading this, Professor He almost knocked over his teacup!

Modify T cells and calibrate the gene characteristics of cancer cells. This step is a technology disclosed by CAR-T. People who study this project all over the world know the operation of this step.

Then there is the Second Step. Lu Li made modifications on the T cells to block the information transmission mechanism of the T cells, so that the T cells no longer "call friendly forces".

This step operation, which Lu Li published in the last paper, has also been verified by major scientific research institutions all over the world, and it is even the best way for countless cancer hospitals to treat advanced cancer patients.

Now, in this paper by Lu Li, the Third Step is given, which is to perform gene editing and modification on B cells, shield the command ability of B cells, and make it no longer frantically release immune factors.

Theoretically, this is a feasible solution.

After closing the paper, Professor He opened the experimental report next to it.

In the experimental report, Lu Li described all the operation steps in detail and wrote all the experimental data.

This lab report is very detailed and can be repeated based on the lab report.

Of course, Lu Li did not write out the data of human experiments. After all, it is not so easy to do human experiments in reality.

After reading the paper and the experimental report, Professor He raised his eyes and looked towards Lu Li, his expression still a little dull.

"So...the cancer has been conquered by you?"

After a while of sluggishness, Professor He suddenly burst out laughing: "hahahaha! My students have conquered cancer!"

"This is a great scientific research achievement! From today, cancer is no longer a nightmare for mankind!"

(end of this chapter)