My Life Simulator

My Life Simulator Chapter 360

2021-10-14

Chapter 359 Gene Chips and Gene Targets

A list of books sent Ms Wenwan away.

Seeing the slightly trembling shoulders of Wenwan girl, Lu Li nods with a smile. Although the basics are a bit poor, the learning attitude is still very correct! After getting my book list, look at her excited!

This is similar to the excitement of... elementary school students after receiving a box of practice questions as gifts?

Are you greedy for my body? You are thinking of peaches!

How can I have the time in America to have a romantic relationship with you? Might as well go back and do an experiment...

Well, Professor He kicked me out of the lab.

Then give the chickens a break... ugh, give yourself a break!

Lu Li turned around and walked out of the institute, ready to go roam around and move his hands and feet.

Just walking to the gate of Fudan school, Lu Li suddenly saw a very familiar silhouette.

In March, the catkins are flying.

The light wind blows the weeping willows along the road, like rippling silk.

A woman wearing a light-colored spring dress, walking in the shade, came in a light lotus step.

"Liu Qin?"

Lu Li was shocked. In this plot, could he still meet Liu Qin? It was... so unexpected.

“Lu Li?”

Hearing the call, Liu Qin hurriedly lifts the head and saw Lu Li standing at the intersection ahead.

The tall and straight silhouette, the handsome face, and the undisguised surprise on his face made Liu Qin's heart tremble inexplicably.

Liu Qin reached out and stroked the hair by his ear, calmed down, and walked up with a smile.

"Scientist Lu, old classmates are coming to visit, are you welcome?"

Walking in front of Lu Li, Liu Qin raised his hand and hit with a smile call.

"yearn for something even in dreams!"

When facing Liu Qin, Lu Li was not steely at all, but very proactive.

Hearing this, Liu Qin's face flushed slightly, pretending he didn't understand the meaning, and quickly changed the subject, "I only found out after reading the news, it turns out... I haven't seen you for a few years, you have He is a world-renowned scientist."

"Just achieved a little insignificant achievement."

Lu Li humbly said to Liu Qin: "How about you? Harvard Have you graduated?"

He knew I went to Harvard for a Ph.D.?

That means...he's been paying attention to me?

Liu Qin had an inexplicable sweetness in his heart, and said to Lu Li: "I have already obtained an Academician degree, and I am planning to find a job!"

"Looking for a job? Your ability, a lot of units are rushing for it!"

Lu Li touted a little, and added: "If there are too many units and you don't know how to choose... or come to Fudan to be a professor Let's go!"

"Come to Fudan to be a professor?"

Liu Qin glanced at Lu Li and said, "Does Fudan have any advantages?"

"The advantage is..."

Lu Li pointed to himself, "You can be closer to me, a handsome scientist."

"Cut~! Smug! "

Liu Qin rolled the eyes towards Lu Li.

The two chatted and laughed all the way, wandering around the Fudan campus.

And then...the gentle girl who was sent a list of books by Lu Li happened to see this scene.

Damn it! What's happening here?

Seeing Lu Li talking and laughing with Liu Qin all the way, Wen Wan's mouth was shaking with anger.

You are so steely in front of me, and you are so humorous in front of her?

You will send me the book list with me, and you will make her happy with her?

I...I can't compare to her at all...

Well, not really.

Although deep in one's heart is reluctant to admit it, but... in comparison, her appearance is not as perfect as Liu Qin, and her proud stalwart mind seems to be one size smaller than Liu Qin .

But...I won't give in! Grab a man with strength, who is afraid of who?

Took a deep breath gently, with a smile on her face, she walked up to meet Lu Li and Liu Qin.

“Lu Li.”

Greeting Lu Li with a gentle smile, and then naturally walked to Lu Li, very close.

"This is..."

Wen Wan glanced at Liu Qin next to her, pretending to be a hostess, said with a smile: "Is this a guest? ?"

Liu Qin's eyes shrank slightly, and an indescribable complexity surged in his heart. This hostess-like tone... Could she be Lu Li's girlfriend?

Lu Li also heard the gentle kiss of the hostess.

Is this intentional? Are you here to tear down my desk on purpose? If so, don't blame me.

So, Lu Li looked up at Wen Wan with a look of doubt on his face, "That... who are you? Do we know each other?"

Hearing this A splendid gleam flashed in Liu Qin's eyes.

But Wen Wan grinned in anger.

I only met half an hour ago, and you sent me a long list of books, so I pretended not to know each other?

You bastard!

Dare you do this to me? See how I clean up you!

So, Wen Wan fiercely pinched her thigh, and the pain caused her tears to flow down.

And then... Wen Wan looked at Lu Li with a sad face, without saying a word, with a heartbroken and weak look.

I'm going! Dramatic!

Fortunately, I am not to be trifled with either!

Lu Li raised his eyes, looked towards Wen Wan, said with a smile: "This girl, you pinched your thighs too much, the weak spot is too obvious."

"If you want to pretend to cry in the future, you can use ginger juice or balsamic oil. Rub a little with your fingertips and wipe your eyes, and the tears will come out, which will be more concealed."

"pu chi! "

Liu Qin next to him couldn't help laughing.

"Bastard! You can find all this? Do you have Microscopes in your eyes?"

Wen Wan grinned, fiercely stomped her feet, turned around and left. Pretending to cry was seen through, and I can no longer play.

"Sharp observation, this is a must for scientific researchers!"

Lu Li waved at Wen Wan, "Student Wen Wan, remember to be serious when you go back. Study. The book list I gave you before, must read it carefully. Next time, I have to check the homework!"

"Damn book list!"

Wen Wanangry roar , the steps of escaping are even more staggered!

After Wen Wan ran away, Liu Qin asked Lu Li, "Is she your student?"

"No!"

Lu Li laughed and replied, "A graduate student from Xiehe Medical College came here to ask me for advice this morning. I saw that her foundation was not very solid, so I gave her a book list."

consult? Asking is just an excuse!

You even gave her a book list? How much steel are you?

But...why weren't you so steely when you were talking to me just now? He has been constantly expressing hints, it seems that emotional intelligence is quite high!

Could it be because of me...

Liu Qin's face was slightly red, but his heart was very happy.

In the next few days, Lu Li and Professor He took a leave of absence and took Liu Qin to play around in Shanghai.

Disney, golf, museums, the happy laughter and cheerful voices of the duo are everywhere.

The life simulator is really amazing, the same girlfriend can fall in love countless times!

A few days later, Liu Qin is going back.

"Lu Li, I'm going back. I've been out for a few days, and my family urged me to go back."

"Then...I'll send you off!"

Later, Lu Li drove Liu Qin to the airport.

Before getting on the plane, Lu Li carried a bag of fruit and handed it to Liu Qin, and said the famous saying: pears are li, and Lu Li's li.

……

"Xiao Lu, sent your girlfriend away?"

When Lu Li returned to the laboratory, Professor He was full of faces. "Aunt Laughs".

"Well, I'll send it back!"

Lu Li nods. "She is considering coming to Fudan to apply for a professorship and needs to discuss with her family"

"Oh? Apply for Professor of Economics?"

Professor He was a little surprised. Could it be that Lu Li's girlfriend is also a scholar?

"She is a Harvard Economics Academician, so it should be no problem to apply for a professor of Economics."

Lu Li replied casually without saying more, "Professor, I will do it. Experiment."

Harvard Economics Academician ? Returnees Academician?

When Lu Li just achieved world-renowned achievements, there appeared a returnee Academician with a background of studying abroad?

Out of prudence and protection of Lu Li, Professor He quickly reported the situation and conducted a political review of Liu Qin.

......

Lu Li was also very happy to meet Liu Qin again.

I fell in love again with my girlfriend in real life. This feeling...is really amazing.

It's just...it's still just a dream.

In this plot, falling in love is only incidental, and Lu Li's goal is still clear, must find a cure for cancer.

In the next time, Lu Li spent more energy and time in the laboratory besides calling and sending messages with Liu Qin.

In the daytime, I do gene comparison experiments in the institute, and at night, I go through the virtual laboratory to continue gene comparison experiments.

It's just...the progress of this experiment is really frustrating.

The DNA chain has three billion base pairs, and it is too much work to compare one after another to confirm the genetic information.

Even if 10,000 base pairs of genetic information can be determined every day, it would take 300,000 days.

A year is three hundred and sixty-five days, and a hundred years is only thirty-six thousand five hundred days. 300,000 days...

Lu Li only slightly compared the data, and felt a deep sense of powerlessness.

Even more how, Lu Li couldn't complete the confirmation of 10,000 base pairs of genetic information in his daily experiments.

It can't go on like this!

Is there any other faster way?

Yes!

At present, countries all over the world are researching a new "gene expression" detection tool, which is called "gene chip".

The sequencing principle of the gene chip is the hybridization sequencing method, that is, the nucleic acid sequence is determined by hybridizing with a group of nucleic acid probes of known sequence, and the target nucleus with the known sequence is immobilized on the surface of a substrate. nucleotide probe.

When the fluorescently labeled nucleic acid sequence TATGCAATCTAG in the solution is complementary to the nucleic acid probe at the corresponding position on the gene chip, a set of complete sequences can be obtained by determining the position of the probe with the strongest fluorescence intensity. complementary probe sequences. Accordingly, the sequence of the target nucleic acid can be recombined. (It came from Baidu, don't ask me, I don't understand)

A gene chip, with countless gene probes integrated into the microgel, can increase the speed countless times in "gene expression detection" .

However, the current gene chip technology is only theoretical research, and the gene chip with real practical value has not yet come out.

But...the theory is enough!

"Virtual gene chip!"

With the order, a rays of light flashed, and a huge glass plate appeared in the laboratory. On this glass plate, numerous gene probe arrays are densely packed.

This is a gene chip.

As long as there is a theoretical basis, the virtual laboratory can virtualize the finished product.

On the basis of the gene chip, it can be combined with optical cable, console, computer, electronic Microscope, monitor and other equipment to form a virtual test bench.

After a while, various components are automatically matched to form a huge genetic testing test bed.

Lu Li was then ready to perform gene expression assays.

There are 100,000 genes whose gene expression information has been confirmed in human beings, but... under the base number of 3 billion, 100,000 can be completely ignored.

An additional advantage of virtual labs is that any experimental material can be produced just by thinking about it.

So...Lu Li virtualized three billion cells with each missing a certain base pair.

Install these cells in the solution tank, start the genetic testing test bench, and let these cells with missing base pairs flow into the gene chip continuously, looping and comparing continuously.

On the display screen, various data surged like a waterfall, and gene expression detection was being carried out continuously.

The solution in the solution tank continuously flows through the gene chip, and it is continuously recovered and circulated without stopping.

This is so much easier!

Just wait for the test to complete and get the final result.

Lu Li put out a long breath, put aside the unimaginably large amount of repetitive work in genetic testing, and began to study more interesting gene targeting technologies.

At present, in gene editing technology, how to accurately position and how to cut the spliced protein to the required position is still a matter of luck.

If all the genes in the DNA chain of the human body can be deciphered and the gene expression information of each base pair can be confirmed, then...it is very important to accurately cut the required gene segment.

If you can hit the right spot at one time, you can hit all the shots without missing the target, it will undoubtedly increase the efficiency of gene editing technology thousands of times.

Existing gene editing technology relies entirely on transcriptase for gene positioning.

Transcriptase equivalent to a radar. After transcribing the target gene, the transcriptase obtains the target information features, and then scans and searches the gene chain to align the target.

After finding the target, the transcriptase combined with the splicing protein will drive the splicing protein to fit the gene chain and cut the target gene.

In theory, this principle is completely correct. It's just that the "radar" is relatively ineffective, often finding the target, or even finding the wrong target.

Now, what Lu Li has to do is how to improve the radar's search capability.

But...it's hard!

Transcriptase is a very simple protein molecule, and there is no probability of replacement on the "hardware device".

The hardware can't do anything, and the only way is to update the software to improve the resolution.

In order to improve the discrimination ability of transcriptase, it is necessary to master all the gene information on the gene chain.

Well, back to square one.

It is still only possible to do gene expression testing first, and then determine the gene expression information of three billion base pairs.

To engage in genetic research depends entirely on how much human beings know about genes!

Long way ahead!

(end of this chapter)