Rebirth of the God-level Xueba

At the end of the meeting, Xu Zhengping figured out Yang Rui's thoughts, and said in amazement: "It's really not right for us to do deferiprone."

Those who do biology do make medicine, but this does not mean that any scholar who does biology can do medicine research, and it is even more unlikely that any medicine can be done just like any medicine.

Yang Rui’s ion channel laboratory normally belongs to the foundation of basic biology. It is already based in the ion channels of cells. It is almost the bottommost biologically active substance that humans can come into contact with. What else? basis.

If in a few years, the rise of targeted drugs, the biologists in the ion channel laboratory are really suitable for drug research, so it’s no problem to transfer to the industry to earn some money.

But right now, the research in the ion channel laboratory is too far ahead of drug research. In addition, I am afraid that the laboratory is not willing to put down and do industrial work. As for Xu Zhengping himself, he gets the same salary anyway, why not stay in the promising laboratory of Peking University and do promising basic research. It is very stressful to write papers. If you take a step slower, the people behind You have caught up, and your previous efforts have been in vain. When you turn around two or three years later, you once occupied the leading front position, and perhaps you have all become the rear.

Choosing to do scientific research is to choose a lifelong competition. A slightly ideal scientific researcher. Starting from the third year of high school, they are basically in the state of the college entrance examination every year. People who can’t stick to it are naturally eliminated. Anyway, a scientific research leader only needs a few to the end. Top people are fine, the rest can be filled with scientific research dogs, just use scientific research dogs, if not, just a few scientific research apes will do.

Only a guy like Yang Rui had enough energy to think about doing something else.

However, Yang Rui also understood Xu Zhengping's thoughts, and only said: "Let's go to the doctor who spoke before to see what the specific situation is like."

He thought to himself, if the ion channel laboratory can't make medicine, then Huarui laboratory will do it.

Although it is not a profitable project, in the end, it should still be able to make money. After all, Yang Rui does not have to worry about the most time-consuming R&D process, nor does he have to worry about not being able to produce results, and these parts are the most risky. As for clinical trials, it’s right to consume energy and time, but the main thing is trouble. The drug level is decent, and clinical trials are always decent. So many countries in the world do not necessarily have to sell them globally.

In fact, Yang Rui doesn't care even if he doesn't make money.

The ultimate goal of his establishment of Huarui Lab is for freedom, not only the financial freedom of simple personal enjoyment, but also the pursuit of ideal financial freedom.

Whatever experiment you want to do, do what you want to do research, this is Yang Rui's ideal-silver chloride, platinum rod, throwing a piece of pure sodium to watch the explosion, making tea with 4 nines...

Rushing Huarui Lab to make a drug that doesn't make much money actually doesn't need any explanation, it's nothing more than money and willfulness.

"I want to see the patient's condition." Yang Rui looked around and said: "It happens to be in the hospital. Ask if you can take a look at it on the spot."

"Okay." Xu Zhengping had no objection. As the deputy director of the ion channel laboratory, he wanted to support Yang Rui, the director, and turned to ask Wang Sisheng: "Xiao Wang, do you know the doctor who spoke just now?"

Wang Sisheng thought, "How could I know each other", turned his head and smiled: "I'll ask."

After a while, Wang Sisheng asked someone to come over and said: "It happens to be a doctor from Xiehe Hospital, called Yong Xiaodong. I reported the name of Director Yang, and they immediately agreed. Now I'm in the inpatient department, and I will send someone to pick us up soon."

After a total delay of less than half an hour, Yang Rui was on the first floor of a building in the inpatient department and saw Yong Xiaodong who was waiting there.

"Director Yang, Director Xu, Comrade Wang..." Yong Xiaodong enthusiastically shook hands with the three of them, then greeted the three scientific researchers who followed, and introduced as he walked: "My current work focuses on thalassemia. It’s sick, you are interested in understanding, I am very happy, this kind of disease, there is too little willing to understand."

Soon, Yang Rui knew why people were unwilling to understand.

It's too awful.

If cancer patients receive chemotherapy and hair loss is a change in appearance, then Thalassemia major can be said to be a change in appearance.

The deformed bones due to compensatory hyperplasia change the patient beyond recognition, but most severely ill patients are children...

Seeing a child with the most elementary school age with deformed face, deformed abdomen, deformed legs, and deformed arms, even the oldest Xu Zhengping couldn't stand it anymore. He couldn't help asking, "Why are all so small?" "

"Thalassaemia major is an early death disease." Yong Xiaodong whispered.

The implication is that the older ones are dead.

Xu Zhengping shook his head and said, "I remember that you gave a report today and said that the average age is between 15 and 20 years old. Here are the ages of elementary school students..."

In fact, it is more than elementary school students. Most of the children are only below the third grade of elementary school, and many of them are kindergarten children, and they don’t even understand what happened...

"Generally, the parents who are sent to our hospital have a glimmer of hope. They cannot be cured by the age of nine and ten. They usually go home." Yong Xiaodong whispered: "People in the north do not suffer from thalassemia. There are many, mainly in the south, especially in Guangdong, Guangdong, Yunnan and Guizhou. There are more thalassemia gene carriers and more patients. They come to the capital, the expense is also high, and if there is no obvious improvement, most of them will choose the hospital at home. Or some are not treated."

"Did you not insist on treatment?"

Yong Xiaodong smiled bitterly: "We can't talk about treatment at all now. Apart from blood transfusion and deferoxamine, there are no other treatment options. Moreover, the cost is very high."

It is not only expensive. Thalassemia major requires long-term blood transfusion and fluid transfusion. Older people require regular blood transfusions if the hemoglobin drops. The time is long, the dosage is large, and the treatment of complications is a daily cost. Doujin.

Yang Rui turned his head and glanced casually, and he could see the decadent father, the sad mother and the painful parents, as well as the numb child.

Less than half a month, blood transfusion at most once a month, iron-removing injections with almost frequency, and dramatic changes in appearance are not enough to make children feel the beauty of life.

Even if iron ketone is developed, life is not good enough.

However, the pressure will be reduced a lot.

Yang Rui thought about it and asked, "If we develop an oral iron deironing agent, will it help?"

Yong Xiaodong's eyes lit up and asked, "Do any pharmaceutical companies produce oral iron deironing agents?"

"Not yet, I want to find out first."

"If there is an oral iron remover, it will definitely help. At least it will allow these families to hold on for a few more years." Yong Xiaodong said unbearably: "Although in the end, the results are still the same, it should be different. ."

Being a doctor for a long time is usually not too emotional, but when facing a group, feelings will be enriched.

Yang Rui looked at his expression and couldn't help but comforted: "Although the final result is the same, the process is different. We are not Gods and cannot change the world, but I think a child who died young at the age of fifteen or six, and at thirty No matter how critically ill, there is still a big difference, at least you can see the world, and the first ten years of life will be easier."

"Moreover, there are patients with intermediate thalassemia, and they can get even more changes."

Yang Rui nodded and introduced the hydroxypyridone compounds studied by hider, and said: "I don't know much about deferiprone, but as far as I know, the structure of deferiprone is electrically neutral and has a certain degree. Is lipophilic and has a small molecular weight, which means..."

"It can be absorbed in the gastrointestinal tract!" Yong Xiaodong reacted immediately.

Yang Rui nodded: "And it can penetrate tissue cell membranes. I don't know how it will behave in cells, but from a better perspective, it should be able to chelate iron atoms in cells."

Normal infants and young children must pay attention to iron supplementation when eating milk powder, but for children with thalassemia, every reduction in iron means that they can extend their life span for a period of time and improve a certain quality of life.

Yong Xiaodong took two steps excitedly, but after a while, he stopped again and said annoyedly: "Unfortunately, there is no pharmaceutical factory that produces the oral iron deironing agent you mentioned. Even if the basic conditions are available, foreign pharmaceutical factories are still unwilling to develop it. ."

The reason why I only talk about foreign pharmaceutical companies is because Chinese pharmaceutical companies have no ability to create original drugs.

The world's pharmaceutical companies are divided into two categories, one is original drug companies, including well-known Johnson & Johnson, Pfizer, Bayer, or Zelican and so on.

In addition to original drug companies, there are also professional generic drug companies.

A generic drug company is a company that conducts generic production after the original drug company’s drug patent expires. For example, Viagra is owned by Pfizer, but when the patent of Viagra expires, Kingo can be sold, and it is not necessarily sold cheaply. Instead, it eliminates the risky drug development process, and the arduous clinical trials are reduced. The cost of hundreds of millions of dollars saves an average of 15 years of research and development time.

In European and American countries, the number of generic drug companies is dozens of times that of original drug companies, and the scale and strength of many companies cannot be underestimated-if you want to copy people, you must have a certain level.

Some generic drug companies are also very large, such as Diwa Pharmaceuticals in Israel, Sandoz in Germany, and Mylan in the United States, all of which are large pharmaceutical companies with annual sales of billions or even tens of billions.

In China, original drug companies basically do not exist, that is, generic drug companies are very small. Except for some commonly used popular products, foreign drugs produced in the 1960s are too late to be copied in China.

Under such circumstances, it is naturally unreliable to count on domestic pharmaceutical companies.

Yang Rui patted Yong Xiaodong and said, "I'll think of a way."

"Can you think of a way?" Yong Xiaodong was obviously disbelieving.

Wang Sisheng couldn't help but said: "We Director Yang has a very good relationship with the British Telecoms."

Yong Xiaodong's lips moved, and he couldn't help but said, "It's useless, the British don't have thalassemia."

"Don't rely on the British, we rely on ourselves." Yang Rui stared solemnly at the next hospital bed. The child on the bed was lying pitifully on the infusion, not knowing whether he was asleep or awake, his chest and legs were thin and bony. Her belly bulged high, the mother sitting on the edge lowered her head, and the doctor came, and just raised her head and lowered it heavily.

Xu Zhengping took a look at Yang Rui's gaze, took a breath, and hurriedly said: "Director Yang, this matter must be considered in the long term."

"I know."

"Director Yang, Yang Rui, making medicine is a study of biochemistry. Let's start from scratch, how can we make it in time!"

"Of course you have to do it as soon as possible." Yang Rui retracted his gaze, sighed in his heart, but secretly made a decision to become his own original drug company.

Even if you are not making money, even if you are losing money, you should start this pharmaceutical company first.

Any scientific research product has never been produced without input.

The biological and pharmaceutical industries are even more typical.

China needs to have its own original drug company.

For industrial and agricultural products, it doesn’t really matter whether you have your own factory or not. Well, international division of labor cooperation, you produce precision machine tools, I produce refrigerators, I need your precision machine tools, and you can’t use electricity. Refrigerator.

The agricultural products are actually nothing remarkable. The US government will not deliberately let the Chinese go hungry, and there is no need for it. It is nothing more than a bit more expensive and a bit poorer in quality.

But the medicine is really different.

As Yong Xiaodong said, British people are not allowed to have thalassemia. Therefore, it is difficult for British pharmaceutical companies to have the urge to make thalassemia drugs ~www.NovelMTL.com~ The reason why it is said that it is difficult is that India is The traditional market in the United Kingdom and South Asia where India is located is a severe area of ​​thalassemia. Therefore, in the end, an Indian company insisted on making desferiprone.

And in Europe, Germany, France, Italy, Spain, or Norway and Denmark, you don’t even need to add adjectives like "difficult". They are completely impossible to make thalassemia drugs because they don’t have any in China. For patients with thalassemia, instead of spending more than ten years studying the drug and risking their unfamiliar place to go abroad for clinical trials, it is better to choose a common disease in their own country to overcome.

In the final analysis, the common genetic diseases of the natives need to be overcome by the domestic pharmaceutical companies.

This will also be the cold reality faced by various countries and nations in the post-gene era.

If you don't invest in scientific research, you don't want to copy it without reference.

If the country is unwilling to invest, people in other countries may sympathize with donations, but they will never donate a first-class scientific research team for 15 years and the same research funding as the bottomless pit.

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